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Archive | March, 2017

The MIQE Guidlines

The Minimum Information for Publication of Quantitative Real-Time PCR Experiments. The MIQE guidelines were introduced to reduce the lack of standardisation in performing and evaluating qPCR experiments. Previously, a lack of consensus was causing several issues within the field. In particular, the publication of insufficient details presented problems when critically evaluating an experiment or attempting […]

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Figure 3 Thermal image of plate showing heated areas

Thermal Uniformity with the xxpress® qPCR Thermal Cycler

qPCR is a molecular biology technique that utilises temperature cycles to amplify and quantify DNA. Thermal uniformity is essential when performing qPCR to ensure repeatable, reliable results. Undershoots can prevent reaction steps from reaching completion, whilst overshoots can cause the sample to degrade.  At BJS Biotechnologies we have developed the xxpress® qPCR thermal cycler which […]

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Groundbreaking Gene Therapy for Retinitis Pigmentosa

Retinitis Pigmentosa (RP) is an x-linked, inherited disease that causes the progressive degeneration of rod photoreceptors in the retina. This disease affects ~15,000 people in Britain and slowly leads to an irreversible form of blindness. There are several genes which can cause RP when mutated. One which is particularly prone to mutations, known as the Retinitis […]

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Design of a Synthetic Yeast Genome

A multidisciplinary team at The Department of Biomedical Engineering, Johns Hopkins University, have designed a synthetic eukaryotic genome. The project, known as Sc2.0, resulted in a highly modified Saccharomyces cerevisiae genome which was ~8% smaller, with 1.1 megabases inserted, deleted or altered.   An open-source framework, called BioStudio, was used to design the genome. It is hoped […]

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