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PCR in drug development

injection

World’s First Malaria Vaccine Trial

Ahead of World Malaria Day tomorrow comes an exciting development. The worlds first malaria vaccine has been given the go ahead for large-scale trials in three African countries: Kenya, Ghana and Malawi. These were selected as the initial countries to test the vaccine because they still have high numbers of malaria cases despite prevention programmes already being in […]

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mosquito

PCR supports alternate combination therapy in malaria

A study presented at the 63rd annual meeting of the American Society of Tropical Medicine and Hygiene (ASMTH) used polymerase chain reaction (PCR) to show that artesunate-mefloquine fixed-dose combination (ASMQ FDC) is as safe and effective as the African standard of care in treating malaria in children in Africa. Malaria is one of the biggest […]

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DNA

PCR helps find gene fusions in lung cancer

Understanding about the genetic changes behind cancer can help doctors create the best treatment patterns for patients. PCR (polymerase chain reaction) has been used to learn more about ROS1 fusion genes in lung cancer in East Asian patients, and look at its impact on clinical outcome and patient prognosis. Patients carrying ROS1 fusion genes can […]

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PCR finds hidden viruses in sepsis

The life-threatening infection sepsis remains a leading cause of death in hospitals. According to a recent study, PCR has been used to spot latent viruses that lay dormant in the body and are reactivated in sepsis. This provides evidence to support a controversial theory that patients with sepsis progress to an immunosuppressed state. When people […]

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mosquito

Using qPCR to learn more about chikungunya

Researchers at the University Malaya Medical Centre in Kuala Lumpur, Malaysia, are using quantitative polymerase chain reaction (qPCR; also known as real time PCR, RT PCR or qRT-PCR) to understand more about how the chikungunya virus replicates. This could lead to better diagnostics, as well as potential targets for therapeutics. Mosquitoes spread the chikungunya virus […]

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Using gene expression analysis to find genetic markers

Biomarkers that can predict the severity of disease, or that can act as targets for new forms of treatment, are very important in tailoring treatment for individuals, and improving both diagnostics and therapeutics overall. Gene expression analysis, which involves the polymerase chain reaction (PCR), plays an important role in identifying and validating genetic markers, as […]

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